Articles & Tech Notes

Changing sample vessel format is an area of Discovery research that can cause problems: sample tracking, sample loss and robotic referencing are among the many drawbacks of having to perform a transfer step. Genevac set out to attempt to “automate” the transfer step within their evaporation systems and developed several concept designs. The final iteration of this is now launched as the SampleGenie™ system, shown in figure 1. SampleGenie comprises a specially designed large volume glass flask that securely seals to a small storage vial, dramatically increasing its capacity. This allows a purified or other large volume sample to be evaporated directly into the small vial. The whole assembly is loaded into the Genevac HT or EZ-2 evaporation system and using a pre-written method evaporated to dryness. SampleGenie guides the compound into the storage vial directly, thus avoiding the costly transfer step that has traditionally been the cause of problems, and reduces the overall process time by between 0.5 to 1 day in the typical laboratory. If an amorphous anhydrous powder is required at the end of this step then an HT series evaporator with LyoSpeed™ can be used to concentrate the large volume into the vial, and then Lyophilise the remaining volume to leave a powder in the vial. A concentration only version is also available for users requiring a wet sample.