Articles & Tech Notes
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Evaluation of an Improved Sample Preparation Method for Quantative Analysis of Very Low Levels of Airborne Polycyclic Aromatic Hydrocarbons for Worker Protection and Health Screening
Introduction Polycyclic Aromatic Hydrocarbons (PAHs) are large class of compounds comprising two or more fused aromatic rings. PAHs are naturally occurring in fossil fuels and their derived products and can be formed during incomplete combustion of carbon based fuels. As such they are a by-product of many industrial processes. PAHs vary greatly in size, nature and hazard to human health, some are not classified as toxic, where as others are known carcinogens. The IARC specified 16 as being of particular interest, others have subsequently added this list. In all, over 100 PAHs have been described. Given the risks and potential risks to human health presented by PAHs, many high risk organisations, such as Foundries, Bitumen Works & Smoke Houses routinely monitor workers and their environment for PAH levels. Typically PAHs are trapped using filters (particulate forms) or resins such as XAD2 (gaseous forms) through which work place environmental air is drawn. Filters may be situated in a small device attached to the workers overalls, or from larger units measuring the air in a wider area. Potential problems exist when recovering the PAHs from the filters and preparing the samples for analysis, principally, losses due to PAH volatility are reported for bi- and tri-cyclic PAHs (ISO11338-2:2003). Therefore, ITGA undertook a study to improve sample recovery and therefore PAH determination when working with low and very low levels of analytes.
Using Innovation to Enhance Revelation: SP Genevac EZ-2 Optimizes Screening for Novel Active Antimicrobial Compounds
Introduction: Penicillin, the first antibiotic, was discovered over 90 years ago and revolutionized medical potential. Before the advent of antibiotics, bacterial infections were a leading cause of death and the downfall of numerous surgical procedures. The capacity of antibiotics to enable patients to recover from severe infection and reduce the risk of infection of surgical wounds took the medical world by storm, leading to their routine use in both the management of disease and in prophylaxis. However, the resultant widespread overuse of antibiotics has led to many bacteria acquiring resistance to several of the most potent antibiotics available. This threatens the future of medical success as even the most efficacious antibiotics have been rendered inactive against life-threatening bacterial pathogens. Hundreds of thousands of lives are lost every year because of antibiotic-resistant infections.